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Researchers studying receptor-specific contributions in cell-based assays often run all three compounds in parallel to isolate the activity of each individual receptor in incretin signalling networks

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reported a patient with a homozygous LOF MC4R variant (p.Arg165Gln) who initially lost 40 kg following Roux-en-Y gastric bypass but subsequently regained all lost weight [68]

Immunity 57 , 700717 (2024)