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Dodex: A hydroxocobalamin-based injection, often requiring refrigeration to maintain potency

Before the promising therapeutic impact of miRNA can be realized, there are several challenges to be addressed, which include but not limited to targeted delivery of oligonucleotides to specific organs, tissues and cell types, poor bioavailability, limited tissue permeability (Stylianopoulos and Jain, 2013), potential drug resistance, and instability (Raemdonck et al., 2008)

Treatment also produces beneficial changes in plasma lipid profiles, decreasing total cholesterol levels by approximately 30%, bringing these values to levels comparable with normal-weight controls

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