Aetiology The aetiology of male infertility can be broadly classified into the following categories: 5 pre-testicular causes, including systemic and endocrine disorders that impair hypothalamicpituitarygonadal function, such as hypogonadotrophic hypogonadism, which can be idiopathic or secondary to pituitary neoplasms, genetic syndromes, trauma, medications or systemic conditions such as thyroid disorders and obesity testicular causes, which are the most common and involve intrinsic spermatogenic disorders, including genetic causes, varicocele, cryptorchidism, infection, injury or trauma, primary ciliary dyskinesia and gonadotoxic exposures such as chemotherapy or radiotherapy post-testicular causes, which relate to impaired sperm transport or delivery and include congenital absence of the vas deferens, vasectomy, and ejaculatory or sexual dysfunction such as erectile dysfunction or premature ejaculation
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