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Mild nausea, constipation, or temporary appetite loss do not require stopping the medication unless they become intolerable after 68 weeks of consistent use

Effective management involves optimising nutrition despite reduced appetite, maintaining hydration, addressing gastrointestinal symptoms, and implementing lifestyle modifications to support energy levels

More than half (56%) of surveyed physicians require patients to attempt non-pharmacological interventions, such as diet and exercise, before considering GLP-1 prescriptions

Two Very Different Drug Classes Phentermine hydrochloride is a sympathomimetic amine anorectic, indicated as a short-term adjunct the labeling says "a few weeks" in a regimen of weight reduction based on exercise, behavioral modification and caloric restriction, in the management of exogenous obesity for patients with an initial body mass index of 30 kg/m or greater, or 27 kg/m or greater in the presence of other risk factors such as controlled hypertension, diabetes or hyperlipidemia

Key Background Novo Nordisk shares are up more than 75% over the last 12 months, far outpacing the European Stoxx 600 indexs less than 10% gains

Crucially, FOXO4-DRI selectively induced apoptosis in senescent TM3 Leydig cells by causing nuclear exclusion of active Ser15-phospho-p53, leading to a significant increase in apoptosis rate and altering pro-apoptotic (BAX, cleaved-Caspase3 increase) and anti-apoptotic (BCL-2 decrease) protein levels