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Clinical trials have found that the A 2A R antagonist istradefylline decreases dyskinesia in PD and could be used as an adjuvant to levodopa treatment

That sentence alone is enough to send anyone currently managing their weight with semaglutide into a spiral of second-guessing

Another paper found that people with a genetic tendency toward low dopamine levels may face higher risk of depression and suicidal thoughts on these medications

Higher circulating vitamin D levels are associated with decreased migraine risk: a Mendelian randomization study

J., Guan, Y

When adverse effects occurred, they were typically mild and transient, with the most common being mild to moderate headaches (similar frequency to placebo groups), minor injection site reactions (redness, slight swelling), and gastrointestinal effects at higher oral doses (nausea, diarrhea)