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We believe this U-shaped dose-response curve occurs due to the possibility that low-dosed TAT-DAT NT returns the abnormally low level of dopaminergic signaling to the physiological range, and therefore normalizes the hyperactivity of SHR rats
Critical for bone healing, less relevant for avascular cartilage but important for subchondral bone supporting cartilage
However, work in the identification of new markers, both biochemical and electrophysiological, offers hope for a better understanding of the ME/CFS pathophysiology and would provide measurable evidence for the ME/CFS diagnosis, helping to validate patients within the health professions and in wider society
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