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Concurrently, to limit the damage caused by excessive inflammation, the body compensatorily initiates an anti-inflammatory response, releasing anti-inflammatory cytokines (e.g., IL-10, TGF-), a state known as Compensatory Anti-inflammatory Response Syndrome (CARS) (50)

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Despite the widespread use of serotonergic medications, benzodiazepines and cognitive behavioral therapy (CBT), therapeutic outcomes remain limited with less than 50% of patients reaching full remission and nearly one-third do not respond to conventional treatments (De Vries et al., 2016)