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Furthermore, cagrilintide 2.4 and 4.5 mg reduced triglycerides and very-low-density cholesterol significantly more than pooled placebo, with similar reductions as seen with liraglutide 3.0 mg

This aligns with previous studies demonstrating that mitochondrial dysfunction exacerbates tau pathology by promoting tau hyperphosphorylation and aggregation, which lead to the neurofibrillary tangles characteristic of AD [39]

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doi: 10.1371/journal.pone.0143741

But ~25% is a defensible midpoint, not a stretch