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The mechanism appears to involve increased serotonin synthesis in substantia nigra (both compacta and reticulata), a regional pattern unlike any existing antidepressant drug, plus potential dopaminergic contributions given the nigrostriatal location
When estrogen levels drop and surge unpredictably during perimenopause, the vestibular system receives mixed signals
Azole antifungals like itraconazole and ketoconazole are also strong CYP3A4 inhibitors
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Henry Sobo uses KPV as part of a broader strategy that blends functional medicine , nutrition , and peptide science
Current Evidence Gaps No direct head-to-head randomized controlled trials comparing Retatrutide and Cagrilintide monotherapy exist in the published literature
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