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moreover, crossing SOD1 G93A mice with mice overexpressing Nrf2 selectively in astrocytes significantly delayed disease onset and extended survival, thus reversing the toxicity of astrocytes expressing human SOD1 G93A mutation to co-cultured MNs [266, 267]

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The difference between a 6-day and an 8-day interval is pharmacologically minimal

Math: 8.5 mg / 0.158 = 53.79 mg