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non-enzymatic actions and the overall significance of DPP-4 for normal physiological regulation in humans and for the pathogenesis of metabolic disease are still largely unknown, targeting the catalytic activity has been harnessed pharmacologically, and DPP-4 inhibitors now play an important part in the therapy of T2DM

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[DOI] [PMC free article] [PubMed] [Google Scholar] 88.Szabo J., Mlynar M., Fejes A., Renczes E., Borbelyova V., Ostatnikova D., Celec P

Emerging research suggests GLP-1s may directly affect the skin by reducing collagen production, accelerating glycation (which stiffens and weakens collagen fibers), and diminishing hydration levels

Originally made by Danish pharmaceutical company Novo Nordisk as a prescription drug for adult patients with type 2 diabetes, Ozempic is now the latest miracle diet pill

We also thank the 'Assistance Publique Hopitaux de Marseille Biobank' (authorization number: AC2013-1786