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SGLT2i Sodium-glucose cotransporter-2 inhibitors (SGLT2i) have recently been demonstrated to exert profound cardio and nephroprotection in large cardiovascular outcome trials (36)

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Interestingly, the role of LRRK2 in the endolysosomal system is becoming increasingly clear, which is further supported by its interaction with the beta-glucosidase 1 (GBA1) gene, which encodes the lysosomal enzyme glucocerebrosidase (GCase) [117, 118]