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On the other hand, CARN-supplemented rats showed reduced MTX levels, which may be explained by enhanced excretion due to improved renal tubular function [79]

Common side effects like nausea, diarrhea, constipation, and abdominal pain may feel more intense or last longer in this population, making individualized dose escalation critical

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Used together for 4 to 8 weeks, they address both sides of the healing equation

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