[DOI] [PMC free article] [PubMed] [Google Scholar] 120.Pei J., Pan X., Wei G., Hua Y
With further in-depth analysis of its regulatory network and continued optimization of activator design, SIRT1 holds significant potential as a breakthrough target for multi-pathway, systemic, and precise intervention in MASLD
consequently, the full model including all explanatory variables was used for all outcomes, for consistency and easy comparison of results
Ehsani, A
This trial demonstrated that an incretin co-agonist (GLP1RAGIPRA) represents an advance over the monoagonist GLP1RA semaglutide in terms of weight loss benefit without an increase in gastrointestinal adverse events
Non-pharmacological strategies like optimised nutrition and physical activity remain foundational, but new drug classes including GLP-1RAs and SGLT2 inhibitors are expanding treatment options