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Earlier Phase 2 data corroborated these findings, showing that up to 82% of participants achieved a target HbA1c of less than 6.5%

41,42 GLP-1R is expressed in the cardiovascular system, and its knockout has implications for cardiovascular function

It has also been reported that GLP-1RAs may have cardiovascular protective effects among individuals with type 2 diabetes, and they therefore provide an attractive therapy option for patients with NAFLD [14]

Akbari P, Gilani A, Sosina O, Kosmicki JA, Khrimian L, Fang YY, et al

2026;34(6):1000-1017.e5

A long-acting glucose-dependent insulinotropic polypeptide receptor agonist improves the gastrointestinal tolerability of glucagon-like peptide-1 receptor agonist therapy