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This peripheral inflammation is a known driver of neuroinflammation, which is implicated in mood disorders, cognitive decline, and neurodegenerative diseases

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11-Hydroxysteroid Dehydrogenase Type 1 Inhibitors Previous studies have shown enhanced conversion of inactive cortisone to active cortisol through the expression of 11-hydroxysteroid dehydrogenase type 1 (11HSD1) in cultured omental adipose stromal cells (218)

Adequate glycine availability theoretically supports this process

But for some, it remains disruptive enough to cause dose reductions or treatment discontinuation

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