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While nutritional VC intake demonstrates chemopreventive effects by scavenging carcinogen-induced reactive oxygen species (ROS) and maintaining genomic stability, high-dose intravenous VC acts as a prooxidant to selectively kill tumor cells via ROS-mediated deoxyribonucleic acid (DNA) damage, adenosine triphosphate (ATP) depletion, and HIF-1 degradation

The mineral most strongly associated with an increased risk of death was iron, which showed a risk increase of 3.9% -- and the risk increased as the dose increased, particularly over 50 mg per day

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Research also connects glutathione deficiency to cardiovascular disease, metabolic disorders, neurodegenerative conditions, and immune dysfunction