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Under normoxic conditions, HIF-1 is degraded by the proteosome, but under sustained hypoxic conditions, HIF-1 dimerizes with HIF-1 (Semenza, 2009) and induces transcription of genes that regulate glucose metabolism including pyruvate dehydrogenase kinase 1 (Semenza, 2009), GLUT1, aldolase A, PGK1, pyruvate kinase M, and lactate dehydrogenase A (Semenza et al., 1994

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doi: 10.1016/j.aca.2011.02.017

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