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When GSH is actively pumped out of the cell, the cytosol is shifted from a reducing to an oxidizing environment

Similarly, refrain from its use if diagnosed with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), or if you've previously experienced a severe allergic reaction to tirzepatide or any of its components

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However, there was no difference in basal sensitivity to erastin2induced ferroptosis in 0 compared to + cells, and pretreatment with nutlin-3 suppressed ferroptosis equally well in both lines (Fig S2E)