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PNPLA1 has a crucial role in skin barrier function by directing acylceramide biosynthesis

Thyroid tumor: People with a history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2) should not use tirzepatide due to the potential risks of thyroid tumors

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Lean muscle growth and fat loss are also possible, but the effects are less than with higher doses

Fatigue, brain fog, tingling in the hands or feet, and irritability are common symptoms