The challenge facing this strategy is that monotherapies often have varying pharmacokinetics and pharmacodynamics including half-life [69], meaning that the balance of target-receptor agonism may vary over time when using two different agents with varying profiles
The following checklist operationalizes the Stabilize Calibrate Accelerate Preserve framework introduced earlier in this guide
The PlexusDx Precision Peptide Genetic Test ($99 add-on) identifies variants in GLP1R (rs6923761) and GIPR (rs1800437) pathways that influence how your body responds to tirzepatide, but does not assess medication storage or stability
They have not been studied in the clinical trials behind those medications
According to the Mayo Clinic, a person starting Zepbound or Mounjaro takes 2.5mg once a week for a month, then advances to a maintenance dose of 5-15mg
Close monitoring for exacerbation or triggering of abnormal eating patterns is critical, as well as prompt referral to a mental health professional when deemed necessary
