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formigenes analogues and oxalate decarboxylase supplements, small interfering RNA therapeutics that target oxalate-producing hepatic enzymes, and experimental CRISPRCas9 approaches and anti-inflammatory strategies

doi:10.1002/jor.20109

Oxidative stress also activates the Kelch-like ECH-associated protein 1 (Keap1)-Nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) redox regulator pathway, releasing Nrf2 to regulate the expression of genes that control antioxidant, inflammatory and immune system responses, facilitating GSH activity

TB-500 acts intracellularly to regulate cytoskeletal dynamics through G-actin sequestration, and engages additional pathways through integrin-linked kinase and AKT signalling

Recently it was demonstrated that treatment with sertraline, an antidepressant drug, may be involved in the pathogenesis of lipid storage myopathy [26]