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doi: 10.1016/j.cca.2022.06.019 185

The reason for this is that there is skewing of X chromosome inactivation such that females with one mutant PDHA1 gene appear to have the X chromosome harboring the wild-type PDHA1 gene inactivated at a higher rate than predicted based upon the normal random X-inactivation process

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It also supports immune function by helping white blood cells stay resilient

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