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Common clinical manifestations include psychomotor retardation, seizures, hypotonia, cortical visual disturbances, cardiomyopathies and malformations, etc

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However, as ActRIIA/B receptors mediate many diverse biologic processes by responding to over a dozen ligands 23,24,25 , there are potential concerns involving chronic long-term blockade of these receptors as a therapeutic approach to increase muscle mass

Most clinical studies assess outcomes at 24 weeks, with continued improvement typically observed through 12 to 24 months of use