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141 Earlier metaanalyses one in nonobese women (14 RCTs) 142 and another in the broader PCOS population (33 RCTs) 143 found that adding metformin to COCPs or antiandrogens improved BMI and glucose tolerance compared with hormonal therapy alone

For antidepressants like SSRIs, absorption may be delayed, but dose adjustments are rarely needed

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Thus, helping to prevent DNA and collagen from being destroyed

It also upregulated heme oxygenase-1 (HO-1) and other antioxidant pathways, likely through HIF-1 activation, thereby reducing oxidative stress (135)