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N-terminal liver-expressed antimicrobial peptide 2 (LEAP2) region exhibits inverse agonist activity toward the ghrelin receptor

Notably, patients in the active phase of the disease exhibit elevated levels of SRB relative to those in remission [101,102,103]

[28] [29] Patients should maintain open communication with their healthcare team, report new symptoms promptly, and never discontinue prescribed medications without medical guidance

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They often become darker after sun exposure, spread gradually across the face, and remain visible despite using topical creams or home remedies