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Activation of this pathway increases the cells ability to neutralize ROS before they can damage proteins, lipids, or DNA

In addition to their structural functions, N-3 PUFA exert anti-inflammatory properties through activation of Peroxisome proliferator-activated receptor gamma (PPAR-), contributing to the downregulation of NF-B-induced cytokine production (e.g., TNF-, IL-6) 34,35,36 , and the upregulation of microglial phagocytosis of A aggregates 37

Hamlyn AN, James O, Douglas AP