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This GH/IGF-1 axis drives several key metabolic effects: Increased lipolysis, particularly in visceral fat Improved mitochondrial function Enhanced muscle protein synthesis Reduced hepatic fat accumulation Improved insulin signaling Crucially, tesamorelin preferentially reduces visceral fat , not subcutaneous fat

During the treatment process, nanomedicine (5 mg/kg) was injected into the tail vein of mice on days 0 and 5, respectively, and US irradiation (10 min, 1.5 W/cm 2 , 1 MHz, 50% duty cycle) was performed on days 1 and 6

Ann Afr Med 2019;18:1216

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Pharmacol Rev 50:335356 Sipos K, Lange H, Fekete Z, Ullmann P, Lill R, Kispal G (2002) Maturation of cytosolic iron-sulfur proteins requires glutathione

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