Incretins are gut-derived peptide hormones, primarily GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide), secreted after nutrient intake to enhance glucose-dependent insulin release from pancreatic cells
Next-generation molecules Newer molecules entering the GLP-1 space, including GLP-3 peptides , mazdutide , survodutide , and orforglipron , each have unique pharmacokinetic profiles that will require their own timing optimization strategies
The weekly GLP-1 medications are unusual in the peptide world because of their engineered long half-lives
The new Medicare program covering GLP-1 weight-loss medications, Wegovy and Zepbound, has sparked significant interest and confusion among seniors
Back DiMarchi, R Efendic, S (1997) 'Use of GLP-1 analogs and derivatives administered peripherally in regulation of obesity', US Patent US6191102B1.Back Drucker, DJ, Habener, JF, Holst, JJ (1 Dec 2017) 'Discovery, characterization, and clinical development of the glucagon-like peptides', Journal of Clinical Investigation , 127/12, 4217-27
For example, foods high in protein such as chicken and eggs, dairy foods such as milk and yogurt, healthy fats such as avocado or olive oil and soluble fibre such as oats and lentils can all increase GLP-1 naturally
