Alpha arbutin works by inhibiting the enzyme tyrosinase, which is responsible for the production of melanin, the pigment that gives skin its color
The cysteine conjugate product is then N-acetylated by N-acetyl-transferase 20
Thus, individuals with a gut microbiome high in p -cresol-producing bacteria and ingesting a diet low in sulfur-containing amino acids may be more prone to acetaminophen toxicity
doi: 10.4049/jimmunol.162.7.3749 215 FujimotoYShimoyamaASudaYFukaseK
Enerson BE, Drewes LR
Mild diarrhea, upset stomach, nausea, a feeling of pain and a warm sensation at the site of the injection, a feeling, or a sense, of being swollen over the entire body, flushing, headache, skin rashes, and joint pain