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Injectable semaglutide, a glucagon-like peptide-1 (GLP-1) analogue, induces 15% to 17.5% weight loss in individuals without diabetes and approximately 9.6% in those with T2D [7]

In order to reduce systemic and hepatic inflammation, the intervention inhibited NF-B signaling, which decreased the hepatic expression of pro-inflammatory cytokines such as TNF- , IL-6, and MCP-1

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When semaglutide activates these pathways, it can trigger changes in neurotransmitter release that sometimes shift circadian rhythm signals or alter how the body processes glucose during sleep

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The lyophilized form is intended to support stability and consistent handling in experimental workflows