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Data analysis Concentration-response curves were fitted using GraphPad Prism (GraphPad Software Inc., CA) using a standard four parameter logistic equation

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I suspect this is from the glucagon agonism of the drug as glucagon stimulates the formation of extra bile acids/bile salts in the liver which can be very irritating to the intestinal lining causing diarrhea

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Appetite suppression Elevated dopamine and norepinephrine levels modulate hypothalamic appetite centers, lowering hunger signals (Prim Care Companion J Clin Psychiatry 2004)