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Leptin overexpression activates Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling, leading to the induction of suppressor of cytokine signaling 3 (SOCS-3), which inhibits IRS-1 and IRS-2, impairing downstream phosphoinositide 3-kinase-protein kinase B (PI3K-Akt) signaling essential for glucose uptake

Retrieved from Goacki, J., Matuszek, M., & Matyjaszek-Matuszek, B