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To minimize treatment interruptions due to adverse reactions, subsequent Phase III clinical trials may adopt a more gradual dose-escalation strategy to reduce the incidence and severity of gastrointestinal discomfort and other adverse events, thereby enhancing patient tolerance and adherence to the medication

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Subjects received a 16 mg afamelanotide subcutaneous implant or placebo every 60 days (Langendonk et al., 2015)

I = 0.0%, p = 0.620)