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The glucose-dependent insulin secretion mechanism of GLP-1R and GIPR agonism means that insulin release is amplified only when blood glucose is elevated, reducing the risk of hypoglycaemia compared to insulin or sulfonylurea-based interventions

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Adults over 50 experience a natural decline in anabolic hormone levels, including testosterone and growth hormone, which slows muscle protein synthesis compared with younger adults

H., Kahathuduwa, C

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The findings further strengthen the competitive positioning of next-generation semaglutide dosing strategies as obesity treatment continues to evolve toward deeper efficacy, improved durability, and more personalised response-based care