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It was FDA-approved for obesity treatment in 2021

The broader evidence base for combining GLP-1-based therapies with growth hormone secretagogues is limited

Now, Lilly recently reported topline results from the ATTAIN-1 phase-3 trial evaluating orforglipron, a once-daily oral glucagon-like-peptide-1 (GLP-1) receptor agonist for adults with obesity or overweight without diabetes

Tirzepatide trials (SURMOUNT-1) published in the same journal by Jastreboff et al

Because three receptor systems are involved, reducing the dose to manage side effects may disproportionately affect one pathway more than others, leading to unpredictable changes in the benefit profile

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