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CAF-conditioned medium inhibited the accumulation of doxorubicin, but not taxol, in prostate cancer cells in a manner that was associated with increased cancer cell glutathione levels

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By employing 3D hydrogels typically characterized by small, micron-sized pores, the Kamm and Swartz labs have shown that (patho)physiologically relevant flow velocities can trigger migration of MDA-MB-231 in the upstream (against the flow) and downstream (with the flow) direction [231, 232]

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To provide the proper cellular context for our mechanistic findings, we tested the PDS5B 17A mutant in biological assays of DNA damage repair, RAD51 focus formation, HR, and replication fork protection and were able to demonstrate that the DNA binding activity is needed for these PDS5B-dependent biological functions