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But what about foods that GLP-1 users still eat

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Folate supplementation may increase methionine and SAM levels 25 and, as a result, improve methylation

The combination is particularly useful for people whose metformin alone hasn't achieved their target blood sugar levels or weight loss goals

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Bottom line: While you technically could take both, the lack of safety data and the high risk of severe digestive issues mean that almost all medical professionals advise against taking orlistat and Wegovy together