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By inhibiting the activation of NF-B, polyphenols reduce the expression of pro-inflammatory genes and the synthesis of inflammatory cytokines and enzymes (271, 272)

Studies show that -synuclein may bind iron directly, promoting its aggregation, while lipid peroxidation products further stabilize toxic oligomers (Wang et al., 2023

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Exclusion criteria for all groups included current or previous psychiatric comorbidities as diagnosed by DSM-5, using a structured interview (The Structured Clinical Interview for DSM-5, SCID-5) [28] if deemed relevant by the investigator, any general medical conditions known to influence energy processing and/or linked to fatigue, current treatment with any medication/supplementation likely to interfere with energy metabolism if deemed relevant by the investigator, contra-indications to magnetic resonance (MR) imaging, pregnancy or breast feeding

Chronic stress, cortisol dysfunction, and pain: a psychoneuroendocrine rationale for stress management in pain rehabilitation