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In particular, one study examined the association between CKD and homocysteine levels in the context of genetic patterns and found that homocysteine was likely to play a causative role in CKD

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Borges-Santos MD, Moreto F, Pereira PC, Ming-Yu Y, Burini RC

Another pathway, mainly operative in the liver involves methylation of phosphatidylethanolamine using S -adenosyl methionine (SAM) as the methyl group donor