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Despite promising experimental and clinical progress, there are several remaining obstacles to overcome before IUSCT is widely accepted clinically
There is a suggestion from pooled data of increased rates of infections, specifically nasopharyngitis and urinary tract infections, which suggests a role for DPP-4 activity in normal immune surveillance, but whether this is clinically significant is still to be established
These requirements result in higher compliance costs and sometimes lead to market entry delays or restrictions for smaller manufacturers
10.4088/JCP.15r09984 J Clin Psychiatry
There is no published safety trial of the combination