The SURMOUNT-5 data on waist circumference is also clinically meaningful: research has shown that each 5-centimeter increase in waist circumference corresponds to a 7 to 9 percent increase in mortality risk, making the 5.4-centimeter additional reduction with tirzepatide a potentially significant benefit.1 That said, semaglutide remains highly effective and is still the right choice for many patients, depending on insurance coverage, cost, tolerance, and individual response
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In addition, individuals who may be vitamin K deficient due to liver failure, those with a propensity to bleed (e.g., bleeding peptic ulcers), and those with inherited bleeding disorders (e.g., hemophilia) or a history of hemorrhagic stroke, should not take -tocopherol supplements without close medical supervision because of the increased risk of hemorrhage (119, 128)
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