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Several large clinical studies, the majority of which are cardiovascular outcome trials, indicate that GLP-1 RA therapy is safe and tolerable for people living with T2DM and compromised renal function, and also suggest that GLP-1 RAs may have renoprotective properties

For example, research conducted in laboratory settings by Santra et al

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The outcomes were examined with a high-end digital photomicroscopy equipment attached to an Olympus light microscope (Japan)

Semaglutide activates a single receptor, GLP-1

Cross-tolerance between ethanol and neurotensin in mice selectively bred for ethanol sensitivity