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Researchers have found an increased expression of renal markers of senescence, such as p16, p19, and p53, in a high-fat-diet-induced mouse model

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50a was prepared by the amide-coupling of 36 followed by condensation into the benzoxazole, whereas regioisomers 50b and 50c were accessed by a CH activation/cross-coupling protocol from 29a and 29 b (Supplementary Scheme 13)

Casein kinase 2 (CK2) is an antiapoptotic kinase that maintains cell survival