Stored triglycerides are mobilized from adipose tissue at rates that can exceed the liver's baseline capacity to process and export them as VLDL (very-low-density lipoprotein)
Healthcare providers can assess whether symptoms represent a true adverse drug reaction, progression of underlying diabetic neuropathy, or an alternative diagnosis requiring specific investigation
Conclusion Overall, persistent use of semaglutide was associated with significant improvements in glycemic and weight control that were maintained after 2 years
Find out what's happening inside your body
Acknowledgements The authors thank Hans-Joachim Wallny (Project Technical Leader) and Nicole Getzmann (Clinical Trial Leader
There is no established contraindication to using NSAIDs with Wegovy , though these medications carry their own considerations: NSAIDs can cause gastrointestinal irritation, including stomach ulcers and bleeding, particularly with long-term use They should be used cautiously in patients with cardiovascular disease, kidney problems, or asthma Taking NSAIDs with food may reduce stomach irritation, though this may be challenging if Wegovy is causing nausea Avoid NSAIDs if experiencing vomiting or dehydration due to Wegovy, as this increases the risk of acute kidney injury Aspirin should not be given to children under 16 years except on specialist advice (due to Reye's syndrome risk) Non-pharmacological approaches: NICE guidance (NG193, NG59, NG226) emphasises the importance of non-drug approaches, particularly for chronic conditions
