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Larger, well-controlled clinical trials are still needed to confirm whether berberine meaningfully supports weight loss

Current guidance is still evolving

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Compliance with Ethics Guidelines This article is based on previously conducted studies and does not contain any new studies with human participants or animals performed by any of the authors

The primary outcome was pain intensity after 4 months of treatment

These are likely mechanisms by which GLP-1 may impact neuropsychiatric conditions. Ziyad Al-Aly, MD I think there is clearly (an) added benefit for several conditions