This assumption is further strengthened after observing an increased expression of pro-apoptotic proteins Bim and Puma , the downstream effector of the Bcl-2 family, in the tumor samples having GG- rather than AA-genotype
Main text Role of oxidative stress in ALS ALS is an adult-onset neurodegenerative disease, characterized by degeneration and loss of upper motor neurons (MNs) in the cerebral cortex and lower MNs in the brainstem and spinal cord [69], leading to progressive weakness of voluntary muscles, and death caused by a diaphragmatic failure within 25 years [70, 71]
Each iron complex was incubated in water with GSH or GSSG in the ratio 1:1 for 1, 3 and 5 min
No animals were used in this study and thus organisms were not allocated into experimental groups
doi: 10.1074/jbc.R113.486464 213 O'NeillLA
In conditions of increased oxidative stress, reduced glutathione (GSH) decreases while oxidized glutathione (GSSG) increases