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[18] [19] Important safety considerations include: Increased risk of hypoglycaemia when combined with insulin or sulfonylureas GLP-1 receptor agonists should not be used in combination with DPP-4 inhibitors [15] [18] These medications are not recommended during pregnancy or breastfeeding You should contact your GP if you experience: Persistent symptoms of hyperglycaemia (excessive thirst, frequent urination, unexplained weight loss) despite lifestyle modifications Difficulty managing your weight despite sustained efforts with diet and exercise Symptoms suggesting complications of diabetes or metabolic syndrome Severe or persistent gastrointestinal symptoms if already taking GLP-1 medications Seek urgent medical attention if you develop severe, persistent abdominal pain (with or without vomiting) which could indicate pancreatitis, or right-sided abdominal pain or yellowing of the skin/eyes which could suggest gallbladder problems

Current Medicinal Chemistry , 19 (1), 126132

Frequency varies: weekly sessions, often with multiple doses initially, then maintenance

That's because GLP-1 drugs slow digestion and help you feel fuller after eating

(2017) 6:e383

It is on its way to also commercializing 9MW0813, an Eylea biosimilar