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466 One study proposed a novel mechanism wherein postprandial GLP-1 release, under normal physiological conditions, inhibits the activity of chemosensory cells in the carotid body, thereby counteracting sympathetic excitability mediated by elevated blood glucose or insulin levels

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The article says Contrave is contraindicated in uncontrolled hypertension, seizure disorder, current or prior anorexia or bulimia, and in anyone taking monoamine oxidase inhibitors

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Worsening metabolic disease from regain increases healthcare utilization, medication costs for diabetes and cardiovascular conditions, and potential surgical interventions

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Phase 3 TRIUMPH adds an intermediate 6 mg step and treats 4 mg, 9 mg, and 12 mg as target maintenance doses depending on the trial arm

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