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For instance, NKCC2 has been found in insulin-secreting -cells (Zhu et al., 2011) or neurons of the hypothalamus (Konopacka et al., 2015), whereas NCC was detected in endothelial and smooth muscle cells, heart, lung and liver (Wang et al., 2015), adipocytes (Zhang et al., 2022a), and -cells as well (Zhang et al., 2022b)

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Injecting into abdominal subcutaneous tissue places the peptide near target organs while providing systemic distribution

In contrast to this necessary balance, there is a considerable misbalance between the studies concerning Se entering the brain or particular brain cells and these on Se leaving the CNS